Efficacy Observation and Analysis for Influential Factors of 49 Cases Acid Rebound in Proton Pump Inhibitors
10.6039/j.issn.1001-0408.2016.23.13
- VernacularTitle:49例质子泵抑制剂酸反跳的临床观察及影响因素分析
- Author:
Cuiao ZHANG
;
Lin WANG
;
Xuesong REN
;
Yaxin WANG
;
Ying YANG
;
Xia YUAN
- Publication Type:Journal Article
- Keywords:
Proton pump inhibitors;
Acid rebound;
Influential factor;
Clinical observation
- From:
China Pharmacy
2016;27(23):3207-3209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the acid rebound in proton pump inhibitors (PPIs) and its influential factors. METH-ODS:Totally 109 patients who treated with PPIs for 1 month in our hospital during Jan.-Dec. 2015 were collected,and telephone visit was conducted after 1 week withdrawal to the data of dyspeptic symptoms were input and scored by modified Glasgow Dyspepsia Sere-rity Score,then divided into no phenomenon group(<5 scores)and acid rebound in proton pump inhibitors group(≥5 scores). All patients were classified by basic diseases,age,gender,whether smoking and alcohol drinking,and phenomenon of acid rebound in PPIs were observed and analyzed. RESULTS:Totally 91 patients were observed,49 were classified as acid rebound in PPIs group. χ2 test showed elderly patients(χ2=5.350,P=0.021)and people with smoking and alcohol drinking(χ2=4.351,P=0.037)were associat-ed with the increased risk of acid rebound in PPIs;exclusion of the effects of gender and basic disease,Logistic regression analysis showed the risk of acid rebound in PPIs in elderly patients were 5.708 times to non-elderly patients [OR=5.708,95%CI(1.946, 16.746),P=0.002];people with smoking and alcohol drinking was 15.281 times to non-smoking and alcohol drinking [OR=15.281, 95%CI(2.748,84.965),P=0.002],the difference was statistically significant(P<0.05). CONCLUSIONS:Parts of patients show ac-id rebound after stopping PPIs,while elderly patients and patients with smoking and alcohol drinking are the high-risk population, which should be paid attention to.
