Clinical Observation of Salvianolate in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmo-nary Disease
10.6039/j.issn.1001-0408.2016.17.33
- VernacularTitle:丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期的临床观察
- Author:
Shutie LI
;
Yeming WANG
;
Yuanli LI
;
Chen CHEN
;
Lei WANG
;
Wei JIANG
;
Fulong LI
- Publication Type:Journal Article
- Keywords:
Salvianolate;
AECOPD;
Invasive mechanical ventilation;
Clinical efficacy
- From:
China Pharmacy
2016;27(17):2402-2404
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy and safety of salvianolate in the treatment of acute exacerbation of chron-ic obstructive pulmonary disease(AECOPD). METHODS:80 AECOPD patients were selected and randomly divided into observa-tion group and control group,with 40 cases in each group. Both groups received mechanical ventilation. Control group was given routine treatment of theophyllinum,bronchodilators and glucocorticoid;treatment group was additionally given Salvianolate injec-tion 200 mg,qd,ivgtt,on the basis of control group. Clinical efficacy was observed in 2 groups,blood hemorheology indexes were also observed before and after treatment. The mechanical ventilation time,ICU residence time and ADR were recorded in 2 groups. RESULTS:Clinical total effective rate of observation group was 95.00%,which was significantly higher than 70.00% of control group,with statistical significance(P<0.05). Before treatment and 2 d after treatment,blood rheology indexes of treatment group were improved significantly(all P>0.05),and whole blood reduction viscosity of control group was improved significantly(P<0.05). Mechanical ventilation time and ICU residence time of treatment group was significantly shorter than that of control group (P<0.05). No ADR was found in 2 groups. CONCLUSIONS:Salvianolate can significantly improve the blood coagulation status of AECOPD patients receiving invasive mechanical ventilation,and has the advantages of good clinical efficacy and low cost of medical treatment.
