Effect of 5 -aminolevulinic acid mediated photodynamic therapy in combination with recombinant hu-man interferon alpha 2b ointment on basal cell carcinoma in elderly
10.11904/j.issn.1002-3070.2016.05.003
- VernacularTitle:5－氨基酮戊酸光动力疗法联合重组人干扰素α2b 软膏治疗老年患者表浅基底细胞癌的临床观察
- Author:
Junmin ZHOU
;
Shaochun DAI
;
Sen ZHOU
- Publication Type:Journal Article
- Keywords:
5-Aminolevulinic acid;
Photodynamic therapy;
Interferon;
Superficial basal cell carcinoma
- From:
Practical Oncology Journal
2016;30(5):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect of 5-aminolevulinic acid mediated photody-namic therapy(ALA-PDT)in combination with recombinant human interferon alpha 2b ointment on superficial basal cell carcinoma(BCC)in elderly.Methods A total of 143 elderly patients with superficial BCC was ran-domly divided into PDT group(n=72 cases)and the surgical group(n=71 cases).The patients in the two groups were given the ALA-PDT in combination with IFN-α2b and routine surgical treatment respectively .The effica-cy after treatment was observed according to surgical wound area , lesion area , recurrence and security during 1 year follow-up.Results The results displayed the complete remission rate of lesion in the PDT group was sig-nificantly higher than that in the surgical group (81.94%vs.57.75%,P<0.05)after treatment,and the total ef-fective rate of BCC was also higher than that in the surgical group ,but no significant difference was identified in the two groups(91.66%vs.81.73%,P>0.05).During 1 year follow-up after treatment,the results showed the rate of recurrence in the PDT group was significantly lower than that in the surgical group (9.72% vs.22. 54%,P<0.05).Moreover,the mean wound area,the lesion area in the PDT group after treatment were also sig-nificantly smaller than that in the surgical group (P<0.05).Conclusion ALA-PDT in combination with IFN is an effective method with lower recurrence and minor trauma in the treatment of superficial basal cell carcino -ma.
