Roles of 15-lipoxygenases in chronic myeloid leukemia
10.3969/j.issn.1000-4718.2016.10.030
- VernacularTitle:15-LO在慢性髓系白血病中作用的研究进展
- Author:
Fen MEI
;
Ruiwei LI
;
Tonghua YANG
;
Yalian SA
- Publication Type:Journal Article
- Keywords:
15-Lipoxygenase;
Arachidonate 15-lipoxygenase gene;
Chronic myeloid leukemia;
Leukemia stem cells
- From:
Chinese Journal of Pathophysiology
2016;32(10):1916-1920
- CountryChina
- Language:Chinese
-
Abstract:
[ ABSTRACT] Tyrosine kinase inhibitors ( TKIs) are now advocated as the first-line treatment for chronic myeloid leukemia ( CML) , but facing resistance and relapse .Leukemia stem cells ( LSCs ) are leukemia-initiating cells as the source of resistance and relapse .It is therefore important to discover the molecular biomarker of LSCs for developing anti -LSC strategies in leukemic therapy .15-Lipoxygenase (15-LO) is a key enzyme in the pathway of arachidonic acid and plays an important role in the occurrence and development of CML , which is specifically required for chronic myeloid LSCs . This review summarizes the influence of 15-LO on the chronic myeloid LSC characteristics of marked survival , self-renewal, proliferation , differentiation and apoptosis .
