Effect Evaluation of Prophylactic Application of Antibiotics in Cardiothoracic Surgery before and after Clini-cal Pharmacist Intervention
10.6039/j.issn.1001-0408.2015.26.39
- VernacularTitle:临床药师干预前后心胸外科手术预防使用抗菌药物效果评价
- Author:
Airong YU
;
Xing FAN
;
Yan ZHAO
;
Shuibo ZHU
;
Huawen XIN
- Publication Type:Journal Article
- Keywords:
Cardiothoracic surgery;
Prophylactic application of antibiotics;
Clinical pharmacist;
Intervention
- From:
China Pharmacy
2015;(26):3720-3722
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of clinical pharmacist intervention on prophylactic application of antibiotics in cardiothoracic surgery. METHODS:Medical records of patients underwent cardiothoracic surgery were collected from our hospi-tal during Mar. to Apr. in 2014 (before intervention) and during Jun. to Jul. in 2014 (after intervention). Those were divided into pre-intervention group(n=115)and post-intervention group(n=119). The prophylactic application effect of antibiotics was com-pared before and after intervention. RESULTS:After intervention,the rates of prophylactic application were decreased significantly from 96.5% to 72.3%;the rationality rate of antibiotics selection was improved significantly from 27.9% to 94.2%;The course of prophylactic medication decreased significantly from(5.4±2.8)days to(2.3±1.8)days;the difference had statistical significance before and after intervention(P<0.01). The postoperative infection rate was decreased from 13.0% to 5.9%,the difference had no statistical significance(P=0.074). The average hospitalization time,average drug costs,and average hospitalization expenses were decreased significantly,the difference had statistical significance(P<0.05 or P<0.01). CONCLUSIONS:Clinical pharmacist inter-vention to prophylactic application of antibiotics in cardiothoracic surgery can control the infection effective and guarantee reason-able and safe use of drugs during perioperative period.
