Progress in epigenetic regulation of the tumor suppressor gene RECK
10.3760/cma.j.issn.1006-9801.2016.08.018
- VernacularTitle:肿瘤抑制基因RECK的表观调控研究进展
- Author:
Shilong NING
;
Xiao MA
- Publication Type:Journal Article
- Keywords:
Neoplasms;
RECK gene;
Epigenetic regulation;
DNA methylation;
Non-coding RNA;
Histone deacetylase
- From:
Cancer Research and Clinic
2016;28(8):565-568
- CountryChina
- Language:Chinese
-
Abstract:
The RECK protein is highly expressed in normal cells and tissues,however,down-regulated in transformed cells or tumor tissues.Subsequent functional studies have demonstrated that RECK owns the tumor suppressor activity.Hence,it is urgent and important to unmask the mechanisms involved in regulation of RECK expression.Epigenetic regulation plays a vital role in modulating gene expression,besides,multiple research also suggested the involvement of epigenetic regulation in RECK expression.The epigenetic regulation mechanisms of controlling the gene expression currently known will be reviewed in this paper.
