Neuroprotective effect of Nrf2/HO-1 signaling pathway in cerebral ischemia combined with diabetes mellitus
10.3760/cma.j.issn.1673-4165.2016.08.015
- VernacularTitle:Nrf2/HO-1信号通路在糖尿病合并脑缺血中的神经保护作用
- Author:
Caihong DENG
;
Jiangquan HAN
;
Jun CAO
;
Yadan FAN
- Publication Type:Journal Article
- Keywords:
Brain Ischemia;
Diabetes Mellitus;
NF-E2-Related Factor 2;
Heme Oxygenase-1;
Oxidative Stress;
Glucagon-Like Peptide 1;
Liraglutide;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2016;24(8):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon and its analogues are a intestinal stimulating insulin screened by the small intestinal L cells. It can smoothly penetrate the blood-brain barrier into the brain tissue and play a neuropro-tective role. Liraglutide and glucagon and its analogues have higher homology. After entering the brain tissue, it is able to bind with the related receptors and activates Nrf2/HO-1 signaling pathway and thus reducing the production of oxidative stress products, increases the glutathione, heme oxygen synthase, superoxide dismutase and other phase Ⅱ detoxification enzymes, promotes angiogenesis, and protects the nerve cells of diabetes combined with cerebral ischemia injury.
