Research progress of a new therapeutic target in hepatocellular carcinoma glypican-3
10.3969/j.issn.1001-1978.2016.11.002
- VernacularTitle:肝癌治疗新靶点GPC3研究进展
- Author:
Lijie XIA
;
Fuchun ZHANG
- Publication Type:Journal Article
- Keywords:
glypican 3;
hepatocellular carcinoma;
antitumor;
tumor marker;
immunotherapy;
target
- From:
Chinese Pharmacological Bulletin
2016;32(11):1486-1489
- CountryChina
- Language:Chinese
-
Abstract:
Glypican-3 ( GPC3 ) plays very important role in the regulation of cell growth and differentiation in hepatocellular car-cinoma ( HCC ) . GPC3 is closely related to the occurrence and development of HCC. A dramatic elevation of GPC3 expression has been reported in a large proportion of HCC, which suggests that GPC3 is remarkably sensitive and specific to the diagnosis of HCC. GPC3 is a potential therapeutic target of HCC. This paper reviews the structure and function of GPC3, the progress of im-munotherapy based on GPC3 of HCC, and discusses the prospect of therapeutic target of liver cancer in the future.
