Research progress in benchmark dose in risk assessment of long-team exposure toxicity
10.7644/j.issn.1674-9960.2016.10.018
- VernacularTitle:基准剂量法在长期暴露毒性评价中的研究进展
- Author:
Hui PENG
;
Qiaofang LI
;
Jian YIN
;
Tingfen ZHANG
;
Jiabin GUO
;
Yimei WANG
;
Shuangqing PENG
- Publication Type:Journal Article
- Keywords:
benchmark dose;
no-observed-adverse-effect level;
risk assessment;
long-term exposure toxicity
- From:
Military Medical Sciences
2016;40(10):851-855
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of risk assessment is to evaluate the permissible exposure level under specific risk factors.To extrapolate the human acceptable daily intake (ADI) and/or reference dose (RfD), the traditional method uses the no-observed-adverse-effect level ( NOAEL ) to quantify toxicity after being divided by uncertainty factor.There are many limitations with NOAEL method in safety evaluation,for it relies too much on experimental design.Benchmark dose ( BMD) approach is a more reliable method with many advantages.BMD approach and its analysis software, the advantages of BMD over NOAEL, the application and methodological perfection in risk assessment of long-team exposure toxicity are presented in this review.
