Clinical Observation of Shuxuetong Combined with Butylphthalide in the Treatment of Acute Massive Cere-bral Infarction in Elderly Patients
10.6039/j.issn.1001-0408.2015.32.41
- VernacularTitle:疏血通联合丁苯酞治疗老年急性大面积脑梗死的临床观察
- Author:
Jialiang LAO
;
Ningyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Shuxuetong;
Butylphthalide;
Acute massive cerebral infarction
- From:
China Pharmacy
2015;(32):4577-4579
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of shuxuetong combined with butylphthalide in the treat-ment of elderly acute massive cerebral infarction. METHODS:76 elderly patients with acute massive cerebral infarction selected were randomly divided into observation group and control group,with 38 cases in each group. Control group was treated with bu-tylphthalide,100 ml,bid;observation group was additionally given shuxuetong 6 ml added into 55 Glucose injection 200 ml, ivgtt,qd,on the basis of control group. The NIHSS,coagulation index,hematocrit,platelet aggregation rate and clinical efficacy were observed in 2 groups before and after treatment. RESULTS:After 14 d treatment,NIHSS of observation group [(3.57±0.25) points] was significantly lower than that of control group [(5.98±1.13)points],with statistical significance(P<0.05);after treat-ment,total effective rate of observation group(81.58%)was significantly higher than that of control group(57.89%),with statis-tical significance(P<0.05);platelet aggregation rate [(52.38±3.74)%] and hematocrit [(36.21±3.26)%] of observation group were significantly lower than those of control group,with statistical significance (P<0.05). Before and after treatment,coagula-tion indexes of both groups had no significant change,without statistical significance(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Shuxuetong combined with butylphthalide is effective in the treatment of elderly acute massive cerebral infarction,and help restore neurological function with good safety.
