Leading effect of PETCO2 on mechanical ventilation in New Zealand white rabbits

VernacularTitle:呼末二氧化碳指导新西兰大白兔机械通气的研究
Author: Junzhe YANG ; Yanhui ZHANG ; Mingchun WU ; Jun TAO ; Xiaoyang SONG ; Zhongbing LUO
Publication Type:Journal Article
Keywords: rabbit; end-tidal pressure of carbon dioxide in artery; mechanical ventilation; electrolyte; blood gas analysis; hemodynamics
From: Journal of Regional Anatomy and Operative Surgery 2015;(3):327-329
CountryChina
Language:Chinese
Abstract: Objective To observe the leading effect of end-tidal pressure of carbon dioxide in artery ( PET CO2 ) on mechanical ventila-tion in New Zealand white rabbits, and to establish parameters for medical animal experiments in terms of hemodynamics, blood gas, blood glucose, electrolyte. Methods 31 anesthetized New Zealand rabbits were practiced tracheostomy tube and mechanical ventilation. Respira-tion rate was 40 breaths/min and tidal volume was adjusted so that PET CO2 was 29 mmHg. Invasive blood pressure, electrocardiogram and PET CO2 were monitored. Blood gas analysis, electrolyte, hemoglobin and blood glucose were tested. Results When PET CO2 was maintained at 29 mmHg, the results were as follows:PH (7.42 ±0.07), 95% confidenceinterval (7.40~7.45);PaCO2(38.5 ±5.8) mmHg, 95%confidenceinterval (36. 4~40. 6) mmHg;BE (1. 45 ± 2. 80) mmol/L,95% confidenceinterval (0. 43~2. 48) mmHg. Conclusion Moni-toring of PET CO2 is good to guide mechanical ventilation in New Zealand white rabbits.