Recombined adenovirus expressing P53 in the treatment of malignant pleural effusion with lung cancer
10.11659/jjssx.01E015006
- VernacularTitle:胸腔内注射重组人p53腺病毒治疗肺癌恶性胸腔积液的临床研究
- Author:
Bo TANG
;
Qunyou TAN
;
Ruwen WANG
;
Jinghai ZHOU
;
Bo DENG
;
Poming KANG
;
Fuqiang DAI
;
Bin JIANG
;
Kai QIAN
;
Shaolin TAO
- Publication Type:Journal Article
- Keywords:
malignant pleural effusion;
rAd-P53 gene;
lung cancer;
quality of life
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(2):192-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the therapeutic efficacy of a recombined adenovirus expressing p53 (rAd-p53) via intrapleural injec-tion in the treatment of lung cancer with malignant pleural effusion. Methods Thirty-six cases with lung cancer and malignant pleural effu-sion were randomly divided into two groups,which were given intravenous injection of Nedaplatin with (observation group,n=20) or without (control group,n=16) intrapleural injection of rAd-p53,respectively. Between the two groups,the efficacy in treatment of pleural effusion, the amelioration of maximal ventilatory volume ( MVV) ,Kamofsky scoring ( KPS) and quality of life were compared. Results The efficacy in treatment of pleural effusion in observation group are significantly higher than that in control group(17/20 vs. 50%,P<0. 05). The cases with KPS≥80 in observation group were significantly increased following treatment (5/20 vs. 11/20,P <0. 05). However,there was no difference with the cases in control group. Conclusion Intrapleural injection of recombinant adenovirus expressing p53 (rAd-p53) is effec-tive to reduce the occurrence of malignant pleural effusion and increase the quality of life remarkably.
