Value of 18F-FDG PET/CT for diagnosis of lymphatic metastasis in patients with non-small cell lung cancer
10.11659/jjssx.10E015145
- VernacularTitle:18 F-FDG PET／CT对非小细胞肺癌淋巴结转移的诊断价值
- Author:
Liping ZHANG
;
Bo DENG
;
Ruwen WANG
;
Jinghai ZHOU
;
Wei GUO
;
Huijun NIU
;
Zheng MA
;
Poming KANG
;
Shaolin TAO
;
Qunyou TAN
- Publication Type:Journal Article
- Keywords:
fuorine-18-fluom deoxy glucose positron emission tomography /computer tomography;
non-small cell lung cancer;
lymph node metastasis;
diagnosis
- From:
Journal of Regional Anatomy and Operative Surgery
2016;25(3):184-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of fuorine-18-fluom deoxy glucose positron emission tomography /computer tomography (18F-FDG PET/CT) in diagnosis of lymph node metastasis in the cases with non-small cell lung cancer ( NSCLC) .Methods From March 2012 to March 2015,167 patients underwent 18F-FDG PET/CT and contrast enhanced CT inspection within 10 days prior to the surgery and were pathologically diagnosed as non-small cell lung cancer(NSCLC) after surgery.With regard to estimation of the lymphatic metastasis,we com-pared the sensitivity,specificity,accuracy,positive and negative predictive value ,and Youden index between the PET/CT and contrast en-hanced CT.Results There were 731 lymph node stations from the 167 patients.Referred to the final pathological results ,PET/CT has screened 143 lymph node stations in true positive set ,26 lymph node stations in false positive set ,61 lymph node stations in false negative set , and 501 lymph node stations in true negative set .Furthermore,the sensitivity,specificity,the positive and negative forecast values ,and Youden index of PET/CT and CT was 70.10%vs.54.19%(P<0.05),95.07%vs.92.23%(P<0.05),88.10%vs.81.67%(P<0.05),84.62%vs.72.85%(P<0.05),89.15%vs.81.67%(P<0.05) and 0.65 vs.0.46 (P<0.05),respectively.Conclusion It is more effective to to precisely validate lymphatic metastasis of NSCLC by using PET /CT than using contrast enhanced CT inspection .Additionally,PET/CT can provide more information for the preoperative diagnosis , staging and the follow-up treatment of lung cancer .
