The research on CDK4 andβ-Catenin expression and clinic significance in glioma
10.11904/j.issn.1002-3070.2015.05.005
- VernacularTitle:脑胶质瘤中 CDK4 和 β-Catenin 表达及临床意义的研究
- Author:
Tianhua DONG
;
Xin SHEN
;
Yanan LIANG
;
Yu LIU
;
Dandan TONG
- Publication Type:Journal Article
- Keywords:
Glioma;
CDK4;
β-Catenin
- From:
Practical Oncology Journal
2015;29(5):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of CDK4 andβ-Catenin and their relevance in glioma. Methods We used immunohistochemistry to detect the expression of CDK4 andβ-Catenin in forty-five glio-ma tissues and eight normal tissues.According to the classification standard of WHO in 2000 classify and grade the tissues.Results There were significant differences of CDK4 andβ-Catenin expressions between normal tis-sues and glioma tissues(P<0.01).The expression of CDK4 and β-Catenin had positive correlation with the pathological grades of glioma and histological type and increased(P <0.05).Furthermore,the expression of CDK4 was positively correlated with the expression ofβ-Catenin in glioma(r=0.52,P<0.01).Conclusion The increased expression of CDK4 andβ-Catenin may have correlation with malignant change of glioma and oc-curance of glioblastoma,and their combination is expected to become an important indicator in assessing malignant glioma.
