The expression and significance of Arg-1 in colon inflammation-related tumors
10.11904/j.issn.1002-3070.2016.04.010
- VernacularTitle:Arg－1在大肠炎症相关性肿瘤中的表达及意义
- Author:
Yangjiazi WU
;
Xiaolin LU
;
Qi ZHAO
;
Yuyan GAO
;
Yanqiao ZHANG
- Publication Type:Journal Article
- Keywords:
Arginase-1;
Adenomas;
Colorectal cancer
- From:
Practical Oncology Journal
2016;30(4):339-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between Arg -1 expression and the clinical pathologi-cal factors ,proliferation and prognosis value in patients with colorectal cancer .Methods The expression of Arg-1 was observed in normal tissues ,chronic inflammatory tissues ,and adenomas inflammatory carcinoma tissues of mice.At the same time,Arg-1 expression was observed in human colorectal cancer adjacent tissues ,inflamed tis-sues and colorectal cancer tissues .Arg-1 expressed in 20 cases colorectal inflammation -cancer model in mice . Arg-1 expressed in 20 normal colorectal tissues .Fiftheen colitis tissues and 110 colorectal cancer tissues were examined by Immunohistochemistry .Statistical analysis was used to analyze the changes of Arg -1 expression in different groups of mice and human colon tissue cases .Results Arg-1 protein expression in normal tissues of mice was gradually increased in colon ,chronic inflammatory tissues,adenomas,inflammatory carcinoma,with sta-tistical significances(P<0.05).Arg-1 expression in para -carcinoma tissue,colitis tissues,colorectal cancer tissues was gradually increased with statistical significance (P<0.05).Conclusion Arg-1 protein is associat-ed with colorectal cancer TNM stage .Arg-1 protein may be involved in occurrence and development process of inflammation-associated colon tumor and may be a candidate of proliferated and prognostic biomarker in patients with colorectal cancer .
