RASSF1A and RASSF1A methylation′s relationship with breast cancer
10.11904/j.issn.1002-3070.2015.04.019
- VernacularTitle:RASSF1 A 及其甲基化与乳腺癌的关系
- Author:
Fulong LV
;
Zetao WANG
;
Jinsong WANG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
DNA methylation;
RASSF1A;
Estrogen receptor-α
- From:
Practical Oncology Journal
2015;(4):372-375
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the most common malignant tumors in women.Early diagnosis plays a very important role in the treatment of breast cancer.Recently,with the development of epigenetics,it gives us a new orientation for early detection for cancers.The most understood mechanism of epigenetics is DNA methyla-tion.Ras associated domain family 1A gene(RASSFlA)promoter methylation occurres in tumor′s early stage,and have a statistically concern with tumor′s TNM stage,invasiveness and outcomes.Moreover,DNA methylation can be reversed,so RASSF1A can be a promising candidate for early breast cancer detection biomarker,and can be a potential orientation for breast cancer treatment.
