The research progress on NAMPT in malignant tumors
10.11904/j.issn.1002-3070.2016.02.014
- VernacularTitle:NAMPT 与恶性肿瘤的进展
- Author:
Guanghao LI
;
Yubao ZHANG
- Publication Type:Journal Article
- Keywords:
NAMPT;
Nalignant tumors;
Progression;
Treatment
- From:
Practical Oncology Journal
2016;30(2):158-161
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide phosphoribosyltransferase( NAMPT) is the rate-limiting enzyme that catalyzes the first step in Nicotinamide adenine dinucleotide( NAD) biosynthesis and regulates biological processes such as metab-olism,growth and apoptosis of cells.In the past few years,a large number of studies have found that expression level of NAMPT is increased in a variety of malignancies,which is associated with the progression and treatment of malig-nant tumors.The research of the mechanism of NAMPT in malignant tumors and molecule inhibitors of the NAMPT have brought new hope and prospect for the treatment of malignant tumors.This article makes a brief review of NAMPT research status in malignant tumors.
