Comparisons of two chemoradiotherapy regimens for locally advanced non-squamous and non-small cell lung cancer
10.11904/j.issn.1002-3070.2014.05.008
- VernacularTitle:局部晚期非鳞非小细胞肺癌同步放化疗两种方案比较研究
- Author:
Lihua LIU
;
Guangying ZHU
;
Anhui SHI
;
Jianhao GENG
- Publication Type:Journal Article
- Keywords:
Locally advanced;
Chemoradiotherapy;
Non-small cell lung cancer;
Docetaxel;
Pemetrexed
- From:
Practical Oncology Journal
2014;(5):420-425
- CountryChina
- Language:Chinese
-
Abstract:
[Abstrct] Objective To compare the short -term tumor response and adverse events of two chemoradio-therapy regimens for locally advanced non -squamous non-small cell lung cancer .Methods From March 2009 to January 2013 ,we recruited 42 patients with stage ⅢNSCLC who had received three -dimensional intensity -modulated radiotherapy combined with chemotherapy .group A treated with radiotherapy combined pemetrexed plus cisplatin and group B treated with radiotherapy combined docetaxel plus cisplatin .We compared the short -term tumor response and adverse events between the two regimens .Results There were 28 cases in group A and 14 cases in group B .There were no significant differences between the two groups in hematologic toxicities ,such as leukopenia,neutropenia,anemia and thrombocytopenia.In non-hematologic toxicities,radiation pneumonitis and cough were no significances respectively (P<0.05).There were no significant differences in other non -he-matologic toxicities,such as liver dysfunction,renal dysfunction,fever,dyspnea,radiation esophagitis,hypody-namia,weight loss,gastrointestinal reactions and skin reactions .The response rate displayed no differences be-tween two groups .Conclusion This study reveals Pemetrexed plus cisplatin group had less non -hematologic toxicities than Docetaxel plus cisplatin group in locally advanced non -squamous non -small cell lung cancer . But there are no differences in the short -term tumor response between the two regimens .
