Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance
10.11904/j.issn.1002-3070.2014.06.004
- VernacularTitle:Caveolin －1的表达与 EGFR 突变在 NSCLC 中的相关性及其临床意义的研究
- Author:
Ruirui XU
;
Liyuan WEN
;
Guoqiang SUN
;
Qingwei MENG
;
Lichun SUN
;
Li CAI
- Publication Type:Journal Article
- Keywords:
Caveolin-1;
EGFR mutation;
Non-small cell lung carcinoma;
Immunohistochemical
- From:
Practical Oncology Journal
2014;(6):498-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to examine expression of Caveolin -1 in non smoking cell lung cancer(NSCLC)and to discusses the relationship between expression of Caveolin -1 and the Epidermal growth factor receptor mutations .Methods Immunohistochemical staining was used to determine the Caveolin -1 ex-pression and ARMS-qPCR was used to measure EGFR mutations in 40 cases of lung cancer tissue .The clinical pathological characteristics and correlations in patients were analyzed .Results The expression of Caveolin -1 in human lung cancer was significantly lower than that in normal lung tissue ,and negatively correlated with EGFR mutations ,which was statistically significant .Conclusion Caveolin -1 expression is negatively correlated with EGFR mutations in non-small cell lung cancer and related to the histologic type .Caveolin-1 may be a molecu-lar target for diagnosis and judgment of NSCLC .
