Expression pattern of innate immunity related microRNAs in human brucellosis
10.3969/j.issn.1000-484X.2016.09.002
- VernacularTitle:固有免疫功能相关的microRNAs在布鲁氏菌病患者中的表达情况
- Author:
Yuanqiang ZHENG
;
Jiuxuan YU
;
Xinrong HAN
;
Yanchun SHI
- Publication Type:Journal Article
- Keywords:
Innate immunity;
microRNAs;
Brucellosis;
Biomarker
- From:
Chinese Journal of Immunology
2016;32(9):1253-1256
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression pattern of 14 innate immunity related microRNAs ( miRNAs) in brucellosis patients.Methods:By using Real time PCR assay, expression levels of 14 miRNAs in serum samples from brucellosis patients and healthy volunteers were analyzed.Results: Of the 14 miRNAs tested, 13 showed decreased expression in brucellosis patients.And significant Ct differences over one were observed for nine of the miRNAs.In them,five miRNAs,including miR-122,miR-145a,miR-155,miR-301a and miR-146a levels significantly decreased in brucellosis patients (P<0.01).Conclusion:Decreased serum levels of miR-122,miR-145a,miR-155,miR-301a and miR-146a are confirmed and may serve as novel biomarkers for human brucellosis diagno-sis.
