Roles of type 2 innate lymphoid cells in the pathogenesis of bronchial asthma

VernacularTitle:Ⅱ型固有淋巴细胞在支气管哮喘发病机制中作用的研究进展
Author: Dandan WANG ; Ruonan CHAI ; Feifei QI ; Song BAI ; Beixing LIU
Publication Type:Journal Article
Keywords: Type 2 innate lymphoid cells; Bronchial asthma
From: Chinese Journal of Microbiology and Immunology 2016;36(8):634-638
CountryChina
Language:Chinese
Abstract: Type 2 innate lymphoid cells ( ILC2s) are recently identified members of the innate lymphoid cell ( ILC) family. These cells are capable of producing Th2-type cytokines such as IL-5 and IL-13 in response to epithelial cell-derived cytokines IL-25 and IL-33 and play critical roles in allergic diseases such as bronchial asthma. Further investigations on ILC2s will enhance the better understanding of type 2 immune responses and may provide new strategies for the treatment of allergic asthma. In this review, we fo-cus on the origin, location and biological function of ILC2s as well as their possible roles in the pathogenesis of bronchial asthma.