Correlation between HLA-G and tumor immunity and its advances
10.7644/j.issn.1674-9960.2016.08.017
- VernacularTitle:HLA-G与肿瘤免疫的相关进展
- Author:
Li CHEN
;
Yansheng DONG
;
Min LI
;
Wenke ZHANG
;
Yuanqing YAO
- Publication Type:Journal Article
- Keywords:
tumor immune;
HLA antigens;
immune escape;
immunity,cellular;
microRNA
- From:
Military Medical Sciences
2016;40(8):691-694
- CountryChina
- Language:Chinese
-
Abstract:
HLA-G belongs to non-classical HLA-class Ⅰ genes.It is expressed in the fetal-maternal interface on the extravillous cytotrophoblast and in such immune privilege tissues as the cornea and pancreas.However, under pathological conditions, such as tumor, inflammatory diseases and post transplantation, HLA-G is expressed abnormally.HLA-G can interact with its acceptors or immune cells and suppress the function of immune cells, which facilitates the escape of the surveillance of the human immune system and the consequent damage.In clinical studies,HLA-G is related to some clinical parameters.This review will focus on the expression, function and regulatory mechanisms of HLA-G in cancer immunology.
