Stereotactic body radiotherapy versus surgery for resectable stage Ⅰ non-small cell lung cancer: a systematic evaluation
10.3760/cma.j.issn.1004-4221.2016.07.006
- VernacularTitle:SBRT对比手术治疗Ⅰ期可手术切除NSCLC系统评价
- Author:
Ge BAI
;
Jianhu CHU
;
Yongxing BAO
;
Chao ZHEANG
;
Le MA
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung/stereotactic body radiotherapy;
Carcinoma,non-small cell lung/surgery;
Systematic review
- From:
Chinese Journal of Radiation Oncology
2016;25(7):690-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of stereotactic body radiotherapy (SBRT) for resectable stage Ⅰ non-small cell lung cancer (NSCLC).Methods Clinical trials of SBRT or surgery for resectable stage Ⅰ NSCLC were collected by computerized search of Cochrane Library,MEDLINE,EMbase,CBM,CNKI,and VIP.Literature selection,quality evaluation,and data extraction were performed by two inspectors based on the inclusion and exclusion criteria.A meta-analysis was performed on the enrolled studies using RevMan 5.3 software.Results A total of four clinical trials involving 410 patients were included.The results of meta-analysis showed that there was no significant difference in 3-year overall survival rate between SBRT and surgery (RR=1.13,95％ CI=0.66-1.94,P=0.66);there was no significant difference in local control rate between SBRT and surgery (RR=0.71,95％ CI=0.26-1.93,P=0.50);patients treated with SBRT had significantly lower incidence rates of grade 3-4 adverse reactions than those treated with surgery (RR=0.29,95％ CI=0.16-0.53,P=0.000).Conclusions SBRT shows equivalent efficacy to surgery in the treatment of resectable stage Ⅰ NSCLC.However,due to the limitations in this systematic evaluation,the conclusion needs to be further confirmed by large randomized controlled trials.
