Neoplasms chemosensitization enhancing effects of nitric oxide donor compounds
- VernacularTitle:一氧化氮供体型化合物化疗增敏效应
- Author:
Caixia ZHANG
;
Yangyun LIU
- Publication Type:Journal Article
- Keywords:
Nitric oxide donors;
Neoplasms;
Chemosensitizer
- From:
Journal of International Oncology
2016;43(9):684-687
- CountryChina
- Language:Chinese
-
Abstract:
The chemosensitivity enhancive mechanism on nitric oxide includes three routes:adjust the expression level of hypoxia-inducible factor-1 α(HIF-1 α),classical nitric oxide signal pathway and combine with the reaction products of other molecules.Traditional nitric oxide donor compounds include nitroferricya-nide,organic nitrates,s-nitrosothiols,azo onium diol aldoxide,non-steroids anti-inflammatory drugs,whose function of antitumor and chemotherapy sensitization caused extensive attention.
