Protect role of Netrin-1 in inflammatory response
10.3760/cma.j.issn.2095-4352.2016.08.020
- VernacularTitle:Netrin-1在炎症反应中的保护作用
- Author:
Zhankai TANG
;
Caiming XU
;
Guixin ZHANG
;
Hailong CHEN
- Publication Type:Journal Article
- Keywords:
Netrin-1;
Inflammation;
Cell migration;
Hypoxia;
Apoptosis
- From:
Chinese Critical Care Medicine
2016;28(8):756-760
- CountryChina
- Language:Chinese
-
Abstract:
Neuronal guidance factor Netrin-1 has been known to be involved in nervous system development by controlling neuronal migration through both chemoattractive and chemo-repulsive signaling by binding different receptors. Netrin-1 has been shown to play a positively regulatory role during inflammatory process recently. Since the chemorepulsive receptors were found in leukocytes, it is suggest that Netrin-1 played a protective role in tissue through inhibiting leukocyte trafficking and accumulating during inflammatory process in researches. It is demonstrated that Netrin-1 can limit inflammatory response through the involvement of inflammatory cascades, attenuate hypoxia-inducible tissue injury and suppress apoptosis concurrently. It is indicated that Netrin-1 can be a novel target in future through preventing and inhibiting inflammatory diseases in these researches. This review will focus on recent relevant advances and in-depth study to elucidate its mechanism of anti-inflammation.
