Study of relationship between Pre-S1 antigen and hepatic function in patients with chronic hepatitis B

VernacularTitle:慢性乙型肝炎患者前S1蛋白与肝功能的关系
Author: Shanhong TIAN ; Cuimin WANG
Publication Type:Journal Article
Keywords: Chronic hepatitis B; Pre-S1 antigen; Alanine aminotransferase; Aspartate aminotransferase
From: Clinical Medicine of China 2016;32(5):424-425
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between Pre-S1 antigen and hepatic function of the patients with chronic hepatitis B.Methods Serum samples of 300 cases with chronic hepatitis B patients were collected,Pre-S1 antigen and alanine aminotransferase (ALT),aspartate aminotransferase (AST) were checked,and the correlation were analyzed.Results Among 300 cases,patients with positive Pre-S1 antigen were 58.33％(175/300).In patients with positive Pre-S1 antigen,the abnormal ALT(＞40 U/L) detection rate was 78.75％ (138/175),the abnormal AST(＞40 U/L) detection rate was 77.17％ (136/175),Pre-S1 antigen negative patients ALT abnormal detection rate was 51.20％ (64/125),AST anomaly detection rate was 42.40％ (53/125).There was significant difference between two groups(x2 =2.875,5.223;P＜0.05).Conclusion In patients with chronic hepatitis B,Pre-S1 antigens can be used as a marker of hepatitis B virus infection,copy and hepatic cell injury.