Impact of neoadjuvant chemotherapy on surgery and prognosis in patients with stage Ⅲ gastric cancer
10.3760/cma.j.issn.1671-7368.2016.05.017
- VernacularTitle:术前新辅助化疗对Ⅲ期胃癌患者手术及预后的影响研究
- Author:
Jun WANG
;
Zhan SONG
;
Yanyan DOU
;
Ke LYU
;
Yuting ZHAO
;
Haiyang ZHANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Chemotherapy,adjuvant;
Surgical procedures,operative;
Prognosis
- From:
Chinese Journal of General Practitioners
2016;15(5):383-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of neoadjuvant chemotherapy on surgery and prognosis in patients with stage Ⅲ gastric cancer.Methods The 90 cases staging Ⅲ gastric cancer were randomly divided into neoadjuvant chemotherapy group and surgery group.Both surgical complications and prognosis were compared.Results The overall effective rate of neoadjuvant chemotherapy was 53％ (24/45),disease control rate of neoadjuvant chemotherapy was 91％ (41/45).Blood loss (t =4.102,P =0.037),local adhesions surgery (x2 =19.756,P =0.000),local tissue necrosis (x2 =13.512,P =0.000),tissue fragility (x2 =12.870,P =0.000) number of cases found in neoadjuvant chemotherapy group were higher than surgery group,and the data were statistically significant.There were no statistically significance between two groups about operation time (t =2.391,P =0.129),tissue congestion (x2 =0.865,P =0.352),postoperative bleeding(x2 =0.720,P =0.396),postoperative fistula (x2 =1.047,P =0.306).The survival time of neoadjuvant chemotherapy group was longer than surgery group,but it was not statistically significant(t =1.086,P =0.372).Conclusions Neoadjuvant chemotherapy could reduce the stage of the gastric cancer and increase the complexity of surgery.Thus preoperative evaluation should be prepared before the surgery.
