Monitoring and its clinical significance of SP-D and interleukin-8 levels in bron-choalveolar lavage fluid of ACOS patients undergoing mechanical ventilation
10.3969/j.issn.1000-484X.2016.07.023
- VernacularTitle:哮喘-COPD重叠综合征机械通气患者肺泡灌洗液SP-D及IL-8意义分析
- Author:
Binfan YUAN
;
Dong WU
;
Ruoyun HE
;
Yalian YUAN
;
Bin WU
- Publication Type:Journal Article
- Keywords:
ACOS;
Mechanical ventilation;
BALF;
SP-D;
IL-8
- From:
Chinese Journal of Immunology
2016;32(7):1035-1038
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the concentration of pulmonary surfactant-associated protein D ( SP-D) and interleukin-8 (IL-8) in the bronchoalveolar lavage fluid (BALF) of ACOS patients undergoing mechanical ventilation (MV). Methods:38 patients with ACOS undergoing MV were involved in the study. According to the APACHEⅡscore, the patients were divided into the remission group (n=20) and the aggravation group (n=18). BALF was collected on the 1st and 5th days after MV. The content of IL-8 and SP-D in BALF was measured by ELISA. The levels of IL-8 and SP-D in BALF of the patients with different severity were compared. Results:The level of SP-D was significantly higher on the 5th day than on the 1st day in the remission group,and it decreased more ob-viously in the worsening group (P<0. 05). The level of IL-8 decreased gradually in the remission group but increased gradually in the worsening group. The level of SP-D was negatively correlated with IL-8 level and APACHEⅡ score. Conclusion:The findings suggest that the levels of SP-D and IL-8 in BALF are correlated with prognosis of ACOS patients undergoing MV,and it may prove to be useful as a guidance of therapy and prognosis.
