Research progress of epithelial mesenchymal transition mediated by FOX family in tumor metastasis
10.3969/j.issn.1001-1978.2016.08.005
- VernacularTitle:FOX家族介导的上皮间质转化在肿瘤转移中的研究进展
- Author:
Zongsheng JIANG
;
Junshan RUAN
;
Shaoming WANG
- Publication Type:Journal Article
- Keywords:
EMT;
FOX;
transcription;
molecular target;
cancer stem cells;
drug resistance
- From:
Chinese Pharmacological Bulletin
2016;32(8):1053-1058
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial mesenchymal transition ( EMT) is one of the important biological processes in tumor invasion and metastasis . However , due to the complexity of EMT signaling pathway and its unclear molecular mechanism , the treatment of EMT is still a worldwide problem .But many studies have proved that EMT is not an irreversible process .In recent years , the research of FOX gene family in EMT shows its important role in tumor metastasis . This review focuses on the FOX-mediated EMT process in many kinds of tumor , aiming to have a better understanding of EMT signaling network , and provide a new target for the effective pre-vention of EMT .
