Two Cases of Trisomy 19 as a Sole Chromosomal Abnormality in Myeloid Disorders.
10.3343/kjlm.2008.28.3.174
- Author:
Soon IL JUNG
1
;
Hee Soon CHO
;
Chae Hoon LEE
;
Kyong Dong KIM
;
Jung Ok HA
;
Min Kyoung KIM
;
Kyung Hee LEE
;
Myung Soo HYUN
Author Information
1. Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea. chscp@med.yu.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Trisomy 19;
Sole chromosomal abnormality;
Myeloid malignancies
- MeSH:
Acute Disease;
Aged, 80 and over;
Anemia, Refractory/*diagnosis/*genetics;
*Chromosomes, Human, Pair 19;
Female;
Humans;
Infant;
Karyotyping;
Leukemia, Myeloid/*diagnosis/*genetics;
Male;
*Trisomy
- From:The Korean Journal of Laboratory Medicine
2008;28(3):174-178
- CountryRepublic of Korea
- Language:English
-
Abstract:
Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired 5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral blood smears suggested that the disease had progressed, but she refused further evaluation. Based on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder; however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or acute myeloid leukemia.
