Progress of miR-221/222 in tumor diagnosis and treatment

VernacularTitle:miR-221／222在肿瘤诊治中的研究进展
Author: Bin LONG ; Linfa LI ; Heqing YI
Publication Type:Journal Article
Keywords: miR -221; miR -222; Epithelial -mesenchymal transition; Apoptosis
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(16):2542-2545
CountryChina
Language:Chinese
Abstract: MicroRNAs(miRNA)are a kind of small non -conding RNA,which negative regulate target genes expression at post -transcription level by binding 3'-untraslation region(3'UTR).Dysregulation of miRNA pro-files relate to cancer,immune disorders,cardiovascular disease,neurodegenerative diseases and metabolic diseases. miR -221 /222 are two similary miRNAs,which share the same promoter and have the same seed sequence.miR -221 /222 usually target to same target genes and co -regulate same processes and act as onco -miRNA roles.Howev-er,miR -221 /222 maybe act as suppressor in cancer which maybe dependent particular context.The roles of miR -221 /222 are reviewed in this article,will provide a comprehensive vision for comprehending the biological process of miR -221 /222 in carcinoma.