Roles of glutamate transporter EAAT2 in occurrence and treatment of depression
10.3969/j.issn.1001-1978.2016.07.002
- VernacularTitle:谷氨酸转运体 EAAT2在抑郁症发病及治疗中的作用
- Author:
Jianxin CHEN
;
Lihua YAO
;
Huiling WANG
;
Zhongchun LIU
;
Xiaoping WANG
;
Ling XIAO
;
Chang SHU
;
Gaohua WANG
- Publication Type:Journal Article
- Keywords:
glutamate transporter EAAT 2;
depression;
antide-pressant;
transport dysfunction;
riluzole;
ceftriaxone
- From:
Chinese Pharmacological Bulletin
2016;32(7):894-897
- CountryChina
- Language:Chinese
-
Abstract:
The glutamate transporter EAAT 2 ( rodent nomencla-ture GLT-1:glutamate transporter 1), which is a predominantly astroglial glutamate transporter in the hippocampus and the pre-frontal cortex , is responsible for the majority of extracellular glu-tamate uptake .The glutamate transporter EAAT 2 can decrease the high levels of glutamate in the synaptic cleft , avoiding gluta-matergic excitotoxicity to damage the glial cells and neurons . Currently, the transporter EAAT2 has become a research hotspot of depression .This article aims to summarize roles of glutamate transporter EAAT2 in the occurrence and treatment of depres-sion.
