Effects of aerosolized prostaglandin E1 before one lung ventilation on lung protection in patients undergo-ing surgery for oesophageal cancer
- VernacularTitle:单肺通气前通气侧肺前列腺素 E1超声雾化对气体交换的影响
- Author:
Dian JIAO
;
Lianbing GU
;
Lijun WANG
;
Pengyi LI
- Publication Type:Journal Article
- Keywords:
One-lung ventilation;
Prostaglandin E1;
Esophageal cancer;
Ultrasonic atomi-zing inhalation
- From:
The Journal of Clinical Anesthesiology
2016;32(7):668-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of aerosolized prostaglandin E1 (PGE1 )via right lung before one-lung ventilation (OLV ) on shunt rate (Qs/Qt ) and oxygenation in patients undergoing surgery for oesophageal cancer.Methods Sixty patients scheduled for elective trans-left-thoracic esophagectomy for esophageal cancer were randomly and single-blindly located into two groups.Patients in each group received different therapy before OLV,namely inhaling PGE1 0.2μg/kg via right lung in group P and inhaling normal saline in group C.The PaO 2 and hemodynamic indicators of two groups were recorded at these points:before OLV(T1 ),OLV 10 min (T2 ),OLV 1 5 min (T3 ),OLV 30 min (T4 ),OLV 60 min (T5 ),OLV 120 min (T6 ),.Results PaO 2 in both groups were declined straightly since OLV and fell to the lowest point at T4 in group C.PaO 2 in group P at T2-T4 were significantly higher than that in group C (P <0.05),and the lowest point of which was recorded at T5 .Qs/Qt in group P was significantly lower than that in group C at T2-T4 (P <0.05).There were no significant differences in hemodynamics indicators between the two groups. Conclusion Inhalation of 0.2 μg/kg PGE1 before OLV via one lung can reduce pulmonary shunt and improve PaO 2 in thoracic surgery patients.
