Overview on the New Dosage Forms of Sirolimus
- VernacularTitle:西罗莫司新剂型的研究概述
- Author:
Mingjie PAN
;
Rong DU
;
Ying CHEN
;
Ge SHAO
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Immune inhibitors;
New dosage forms
- From:
China Pharmacist
2016;19(6):1183-1186
- CountryChina
- Language:Chinese
-
Abstract:
In the middle of 1990 s, it was discovered that sirolimus had inhibitory effect on the proliferation of T lymphocytes , therefore, it is used for the treatment of anti-tumor cells.At present, the dosage forms of sirolimus are capsules , oral liquid and tab-lets.However, because of good fat-soluble and poor water-soluble property, its bioavailability is low with many side reactions .In order to provide reference for the further studies of sirolimus , the literatures in recent years were searched in Pubmed , Springer, CJFD,VIP Chinese periodical database and Wanfang data , and the research progress in the new dosage forms of sirolimus was summarized .
