Advances of TGF-β-induced long non-coding RNAs in tumors
10.3969/j.issn.1000-8179.2016.13.441
- VernacularTitle:TGF-β诱导的长链非编码RNA在肿瘤中的研究进展
- Author:
Cui LI
;
Daiqing WEI
;
Jinbo LIU
- Publication Type:Journal Article
- Keywords:
TGF-β;
lncRNA;
tumor;
induce
- From:
Chinese Journal of Clinical Oncology
2016;43(13):581-584
- CountryChina
- Language:Chinese
-
Abstract:
The TGF-βsignaling pathway plays a crucial role in regulating cell proliferation, differentiation, and apoptosis. This pathway exerts either tumor-suppressing or tumor-promoting effects, which are cell-or context-dependent, making it simultaneously advanta-geous and disadvantageous in the process of carcinogenesis and tumor progression. Long non-coding RNAs (lncRNAs) do not encode proteins, but they are involved in the regulation of various signaling pathways and biological functions. Moreover, lncRNAs can induce tumor angiogenesis, as well as affect tumor proliferation, invasion, and metastasis by acting as oncogenes or tumor-suppressor genes. Recent studies revealed that some lncRNAs may be induced and regulated by TGF-βto form a complicated crosslinked regulatory net-work. This review focuses on the crosstalk between the TGF-βsignaling pathway and TGF-β-induced lncRNAs.
