Expression level of IL-25 and IL-33 mRNA in nasal mucosa of allergic rhinitis mice

VernacularTitle:变应性鼻炎小鼠鼻黏膜lL-25、lL-33 mRNA表达水平的研究
Author: Zhaowei GU ; Yunxiu WANG ; He ZHAO ; Zhiwei CAO
Publication Type:Journal Article
Keywords: Rhinitis,Allergic,Perennial; Rhinitis,Allergic,Seasonal; interleukin-25; interleukin-33
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2016;23(3):155-158
CountryChina
Language:Chinese
Abstract: [ABSTRACT]OBJECTIVETo investigate the expression levels of IL-25 and IL-33 mRNA in the nasal mucosa of allergic rhinitis(AR) mice.METHODSBalb/c mice were used for establishing the animal model of allergic rhinitis with oval bumin sensitization as AR group, at the same time, the physiological saline as the control group. IL-25 and IL-33 mRNA in nasal mucosa of the two groups were detected by real-time quantitative PCR.RESULTSThe expression of IL-25 and IL-33 mRNA could be detected in both the control and AR group. The expression level of IL-25 and IL-33 mRNA in AR group were significantly higher than that in control group, the difference was statistically significant (P<0.05).CONCLUSIONIL-25 and IL-33 were involved in the development of allergic rhinitis. This result will be helpful for the further understanding of the pathogenesis of allergic rhinitis, and provide a theoretical basis for the treatment of allergic rhinitis.