Expression of Serum Anti PLA2 R Antibodies in Idiopathic Membranous Nephropathy
10.3969/j.issn.1671-7414.2016.03.002
- VernacularTitle:特发性膜性肾病患者血清抗PLA2R抗体表达研究
- Author:
Tao ZHU
;
Yong ZHAO
;
Mengle PENG
;
Xiaoqing SHI
;
Dongchun QIN
- Publication Type:Journal Article
- Keywords:
idiopathic membranous nephropathy (IMN);
anti M phospholipase A2 receptor antibody (PLA2R);
IgA nephrop-athy(IgAN);
thrombospondin type-1 domain-containing 7A (THSD7A)
- From:
Journal of Modern Laboratory Medicine
2016;31(3):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of serum anti M phospholipase A2 receptor (PLA2R)antibody in idiopathic membranous nephropathy (IMN),and to investigate its value in the diagnosis and evaluation of idiopathic membranous ne-phropathy.Methods One hundred and eighteen patients with biopsy-proved glomerular diseases were involved in this study, including 97 cases with IMN,21 cases with IgA nephropathy (IgAN)and 19 healthy people.ELISA was used to detect ser-um anti-PLA2R antibodies.Correlations of anti-PLA2R antibody level with laboratory parameters,including serum albumin, 24-hour urine protein of IMN patients were evaluated.Results The median of anti PLA2R antibody in IMN group,IgAN group and healthy group was 45.2(3.6~705.9)RU/ml,5.9(2.3~10.6)RU/ml and 1.2(0.6~9.3)RU/ml.The levels of serum anti PLA2R antibody in IMN group were higher than those in IgA nephropathy group and healthy control group.The difference was statistically significant (t=-5.027,-3.077;P=0.05).Among 97 cases with IMN,76 cases showed posi-tive anti-PLA2R antibodies (positive rate 78.35%).There was none patient showed positive anti-PLA2R antibody respec-tively in IgAN and healthy people.Furthermore,anti-PLA2R antibody level was negatively correlated with serum albumin (r=-0.453,P=0.000)and positively correlated with CREA,TC,ESR,24 hour urine protein (r=0.233,0.234,0.363, 0.586;P=0.004,0.217,0.021,0.000)in IMN patients.Conclusion Serum anti PLA2R antibody may be used as a IMN specific marker for the diagnosis of IMN,and it has important reference value for evaluating the severity of IMN.
