Frequency of c-kit mutation and prognosis in t(8;21) acute myeloid leukemia patients with trisomy 4
10.3760/cma.j.issn.1009-9921.2016.06.003
- VernacularTitle:伴4号染色体三体异常的t（8；21）急性髓系白血病c-kit基因突变的发生及患者预后
- Author:
Shimeng JI
;
Aining SUN
;
Suning CHEN
;
Zhao ZENG
;
Shengli XUE
;
Hongjie SHEN
;
Jundan XIE
;
Depei WU
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,acute;
Trisomy 4;
c-kit;
t(8;
21);
Prognosis
- From:
Journal of Leukemia & Lymphoma
2016;25(6):330-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the frequency of c-kit mutation and prognosis in t (8;21) acute myeloid leukemia (AML) patients with trisomy 4. Methods A total of 145 de novo t(8;21) AML patients from February 2005 to January 2013 were analyzed retrospectively. Detection of exons 8 and 17 mutation of c-kit by PCR and cytogenetic analysis by R-banding technologies were performed on bone marrow samples of all patients at diagnosis. Clinical data were collected and analyzed statistically. Results Among 145 t (8;21) AML patients, 12 cases (8.3 %) were trisomy 4, 91.7 % (11/12) of them were identified with c-kit mutation, which was significantly higher than that without trisomy 4 [26.3 % (35/133), P< 0.01]. The follow-up data showed that the patients with trisomy 4 were correlated with the lower overall survival (OS) rate (15 % vs 56 %, P< 0.01) and disease-free survival (DFS) rate (0 vs 51 %, P< 0.01) when compared with patients without trisomy 4. Furthermore, the subgroup of patients with both trisomy 4 and c-kit mutation had a worse OS and DFS (P< 0.05). Conclusions Trisomy 4 is associated with high frequency of c-kit mutation and demonstrates poor prognosis in t(8;21) AML patients. Trisomy 4 or it combined with c-kit gene mutation is the main influencing factor on the survival of the patients with t(8;21) AML.
