Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's Disease.
10.3346/jkms.2017.32.4.599
- Author:
Kyu Yeun KIM
1
;
Do Young KIM
;
Jimyung SEO
;
Yuri AHN
;
Dong Soo KIM
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. DSKIM6634@yuhs.ac
- Publication Type:Original Article
- Keywords:
Behçet's Disease;
Human Papilloma Virus;
Enzyme-Linked Immunosorbent Assay;
IgG Antibody
- From:Journal of Korean Medical Science
2017;32(4):599-604
- CountryRepublic of Korea
- Language:English
-
Abstract:
Quadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated with Behçet's disease (BD). However, no reports have described HPV infection as a possible cause for the development of BD. The objective of this study was to evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased in BD. Serum samples from 93 Korean BD patients, who fulfilled the diagnostic criteria of the International Study Group for BD, were used in an enzyme-linked immunosorbent assay (ELISA). The clinical activity of BD was evaluated at the time of blood sampling. HPV-16 L1 virus-like particle (VLP) antigen was used in this study for the ELISA. Patients with BD had significantly higher antibody titers against HPV-16 (optical density [OD], 0.210–3.675; mean 0.992) than that of healthy controls (OD, 0.248–0.762; mean 0.517; P < 0.001). Using a receiver operating characteristic (ROC) analysis, a cut-off value of 0.578 OD for the anti-HPV antibody titer was determined that differentiated BD patients from healthy controls. When we compared the clinical features of BD between the 2 groups, articular involvement of BD was more likely in patients with an anti-HPV-16 antibody titer < 0.578 OD (P = 0.035). In addition, patients with an anti-HPV-16 antibody titer < 0.578 were significantly younger than those with a titer ≥ 0.578 OD. HPV itself may be a possible extrinsic triggering infectious agent causing the development of BD.
