Intellectual development in preschool children with early treated congenital hypothyroidism.
10.6065/apem.2017.22.2.102
- Author:
Min Kyoung SEO
1
;
Jong Seo YOON
;
Chul Hwan SO
;
Hae Sang LEE
;
Jin Soon HWANG
Author Information
1. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. seaon98@naver.com
- Publication Type:Original Article
- Keywords:
Congenital;
Hypothyroidism;
Intellectual disability;
Synthyroid
- MeSH:
Child;
Child, Preschool*;
Congenital Hypothyroidism*;
Female;
Humans;
Hypothyroidism;
Infant, Newborn;
Intellectual Disability;
Intelligence;
Multivariate Analysis;
Neonatal Screening;
Reference Values;
Retrospective Studies;
Thyroid Gland;
Thyroxine
- From:Annals of Pediatric Endocrinology & Metabolism
2017;22(2):102-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH. METHODS: We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence. RESULTS: The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76–126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0–9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0–16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis. CONCLUSION: IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment.
