Expression and significance of IL-37 and proinflammatory cytokines in peripheral blood of patients with moderate to severe psoriasis vulgaris before and after treatment

VernacularTitle:中重度寻常型银屑病患者治疗前后外周血白细胞介素－37、促炎因子的表达变化及意义
Author: Qi HE ; Xianming PI ; Quan SHI ; Hongxiang CHEN ; Jiawen LI ; Yingxiang YANG
Publication Type:Journal Article
Keywords: Psoriasis; Acitretin; Inteleukin-37; Interferon-γ; Inteleukin-17
From: The Journal of Practical Medicine 2016;32(8):1261-1264
CountryChina
Language:Chinese
Abstract: Objective To explore the expression alteration and significance of inteleukin (IL)-37 in pso-riasis valguris (PV) patients. Methods Patients with PV had been treated with oral acitretin for 8 weeks. PASI score, ELISA and qRT-PCR were used to exam the data of 38 patients (PV group) and 32 controls (control group). Results IL-37 in PV group was significantly higher than that in control group (P < 0.001) and IL-37 changed slightly after 4 weeks of treatment(P > 0.05) but decreased obviously after 8 weeks(P < 0.001). Signif-icant correlations existed among PASI scores, IL-37, IFN-γ and IL-17, as well as among IL-37 and IFN-γ, IL-17 (P < 0.05). Conclusions The increase of IL-37 is relevant to PV development and is associated with pa-tients’ conditions, IFN-γ and IL-17 but the alteration of IL-37 is not related with IL-4.