The expression of MiR-34a/c in lesions of psoriasis vulgaris Uyghur and Han patients in XinJiang

VernacularTitle:MiR-34a/c在新疆维吾尔族、汉族寻常型银屑病皮损中的表达
Author: Chunli CHEN ; Zongfeng ZHAO ; Huiqin WANG ; Weidong WU
Publication Type:Journal Article
Keywords: MicroRNAs/ME; Psoriasis/ME
From: Journal of Chinese Physician 2015;17(11):1658-1661
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression differences of MiR-34a/c in lesions of psoriasis vulgaris Uyghur and Han patients and beside-lesional tissue and normal skin tissue in XinJiang.Methods Real-time fluorescent quantitative polymerase chain reaction (PCR) was used to determine the expression levels of MiR-34a/c in the psoriasis vulgaris Uyghur and Han patients with lesion tissues, beside-lesion tissues, and normal skin tissues, respectively.Results The expression level of MiR-34a was higher in lesions of psoriasis vulgaris in XinJiang than in the beside-lesion tissues and normal skin tissues, and differences were statistical significance (P ＜ 0.05).However, the expression level of MiR-34a in beside-lesion tissues and normal skin tissues, and in the Uyghur and Han psoriasis vulgaris werent statistically significant difference (P ＞ 0.05).The expression level of MiR-34c in three types of tissues and in the Uyghur and Han psoriasis vulgaris weren't statistically significant difference (P ＞ 0.05).Conclusions MiR-34a might participate in the pathogenesis of Uyghur and Han psoriasis vulgaris in XinJiang.