Anti-cancer effect of metformin and regulation on HIF-1α
10.3760/cma.j.issn.1673-422X.2016.02.009
- VernacularTitle:二甲双胍抗肿瘤及调控HIF-1α的作用
- Author:
Junrong GAO
;
Ti ZHANG
;
Manqing CAO
;
Xuejun ZHANG
;
Xiaolin ZHU
- Publication Type:Journal Article
- Keywords:
Metformin;
Neoplasms;
Hypoxia-inducible factor 1,alpha subunit
- From:
Journal of International Oncology
2016;43(2):113-115
- CountryChina
- Language:Chinese
-
Abstract:
Studies show that metformin inhibits the proliferation of several types of cancer cells.All evidences,therefore propose the anti-tumor effect of metformin.Metformin can repress the oxygen consumption of tumor cells,and suppress hypoxia-inducible factor-1α (HIF-1ct) accumulation through the translational and posttranslational mechanisms,and suppress the expression of HIF-1α by activating AMP-activated protein kinase (AMPK).
