Mechanism of curcumin resisting esophageal cancer
10.3760/cma.j.issn.1673-422X.2016.05.015
- VernacularTitle:姜黄素抗食管癌的机制
- Author:
Ruonan TIAN
;
Jianjing SUN
;
Linxi ZHANG
- Publication Type:Journal Article
- Keywords:
Curcumin;
Esophageal neoplasms
- From:
Journal of International Oncology
2016;43(5):379-381
- CountryChina
- Language:Chinese
-
Abstract:
Curcumin can suppress the proliferation of esophageal cancer cells by inducing cell cycle arrest and blocking Notch signaling pathway,and can inhibit the invasiveness of esophageal cancer cells by inhibiting the nuclear factor-κB (NF-κB) signaling pathway and suppressing the formation of tumor blood vessels and inhibiting matrix metalloproteinase (MMP).Curcumin can also regulate apoptosis of esophageal cancer cells by changing the expression and localization of nucleophosmin.
