Preliminary analysis of the efficacy of helical tomotherapy combined with targeted therapy for stage Ⅳ non-small cell lung cancer
10.3760/cma.j.issn.1006-9801.2016.03.004
- VernacularTitle:螺旋断层调强根治性放疗联合靶向治疗对Ⅳ期非小细胞肺癌疗效的初步分析
- Author:
Jing FANG
;
Lili HU
;
Dongshu CHANG
;
Ping LI
;
Weizhang WU
;
Yingjie WANG
;
Tingyi XIA
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Targeted therapy;
Radiotherapy
- From:
Cancer Research and Clinic
2016;28(3):158-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and security of helical tomotherapy (radical radiotherapy) combined with targeted therapy for stage Ⅳ non-small cell lung cancer (NSCLC).Methods The data of 19 patients with stage Ⅳ NSCLC were retrospectively analyzed.The efficacy and security were observed by SPSS 20.0 statistical software.Results Among 19 patients, there were 6 cases complete remission (CR), 8 cases partial remission (PR), 4 cases stable disease (SD), 2 cases progressive disease (PD).The response (CR+PR) rate was 73.7 ％ (14/19).The 1-and 2-year local control rates were 73.7 ％, 47.4 ％,respectively.The 1-year progression-free survival rate was 31.6 ％.The median survival time was 13 months, and the 1-and 2-year overall survival rates were 52.6 ％, 26.3 ％, respectively.The median survival time of females, non-smokers or targeted therapy synchronous radiotherapy was longer than that of male, smokers or targeted therapy sequential radiotherapy, respectively (21 months vs 8 months, P =0.014;21 months vs 6 months, P =0.007;18 months vs 6 months, P =0.026).There were no significant differences of age, number of metastatical organs or targeted drug categories between two groups (P ＞ 0.05).All patients could tolerate the adverse reactions without treatment-related death.Conclusion The effect of helical tomotherapy combined with targeted therapy for stage Ⅳ NSCLC is desirable.
