Establishment of normal reference ranges for clinical pathology indexes of Beagle dogs in GLP system
10.7644/j.issn.1674-9960.2016.02.017
- VernacularTitle:GLP体系下比格犬临床病理学指标正常参考值的建立
- Author:
Li JIA
;
Yimei WANG
;
Lijun ZHANG
;
Lizhong LI
;
Shuangqing PENG
- Publication Type:Journal Article
- Keywords:
Beagle dogs;
pathology;
clinical;
normal reference;
alkaline phosphatase;
erythrocyte;
hemoglobin;
hem-atocrit
- From:
Military Medical Sciences
2016;40(2):147-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the normal reference ranges of clinical pathology for Beagle dogs in the Good Laboratory Practice ( GLP ) system.Method Sixteen biochemical indexes , seventeen hematological indexs and three coagulation function indexes of 117 Beagle dogs were detected , and the mean value of each index and the normal reference ranges were calculated and compared .Results Only alkaline phosphatase ( ALP ) from the biochemical items was significantly different between males and females (P<0.01),which was higher among males than among females .Three in-dexes of hematology were significantly different between males and females (P<0.01),with red blood cell(RBC), hemo-globin(HGB)and hematocrit(HCT)lower among males than among females.The coagulation function items were not signif-icantly different between the two sexes .Conclusion Some indexes of clinical pathology were significantly different between males and females , which should be considered during statistic analysis on toxicity .Our study has established the normal reference range of clinical pathology for Beagle dogs in the GLP system , which provides reference for toxicity tests .
