Meta-analysis of the association between Trp64Arg polymorphism in β3-adrenergic receptor gene and overweight/obesity in children
10.3760/cma.j.issn.1000-6699.2016.02.008
- VernacularTitle:儿童超重／肥胖与β3肾上腺素受体基因Trp64 Arg多态性的关联meta分析
- Author:
Jing WU
;
Zhouyang JIAO
;
Jing ZHANG
;
Qiang LUO
;
Yufeng LIU
;
Jindou AN
;
Peichao TIAN
;
Haohao ZHANG
- Publication Type:Journal Article
- Keywords:
β3-adrenergicreceptor;
Polymorphism;
Children;
Obesity;
Meta-analysis
- From:
Chinese Journal of Endocrinology and Metabolism
2016;(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] In this study, PubMed, Embase, China National Knowledge Infrastructure, databases VIP Chinese Periodical Database, and Wanfang Chinese Periodical Database were systematically searched for the case-control study related β3-adrenergic receptor ( ADRB3 ) Trp64Arg gene polymorphism to overweight/obesity among children from 1962 to 2014.Twelve eligible studies with 2 222 overweight/obese children and 1 955 normal children were included according the uniform inclusion and exclusion criteria.Meta-analyses showed that Trp64Arg polymorphism was associated with significantly increased overweight/obesity risk in Arg carriers among children( OR=1.34,95%CI1.17-1.53).Afterstratificationforethnicity,highlysignificantcoorelationofTrp64Argpolymorphism to overweight/obesity in Asian children(OR=1.44, 95%CI 1.23-1.68) but not significant in Europe(OR=1.05, 95%CI 0.79-1.40).It suggested that Trp64Arg polymorphism is associated with overweight/obesity susceptibility in children.Our results support an strong association between Trp64Arg polymorphism and overweight/obesity among the Asian children investigated.
