B-type natriuretic peptide and risk of type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2016.02.004
- VernacularTitle:B 型尿钠肽与2型糖尿病发生风险相关
- Author:
Min YANG
;
Changlin NI
;
Baocheng CHANG
;
Yunzhao TANG
;
Yanjuan ZHU
;
Chenguang LI
;
Zhenhuan JIANG
;
Ping YU
- Publication Type:Journal Article
- Keywords:
B-type natriuretic peptide;
Diabetes mellitus,type 2;
Impaired glucose regulation
- From:
Chinese Journal of Endocrinology and Metabolism
2016;(2):103-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of NH2-terminal pro-B-type natriuretic peptide ( NT-proBNP) with the risk of type 2 diabetes.Methods One hundred and twenty-six impaired glucose regulation( IGR) participants from Diabetic Identification Center of Tianjin Metabolic Diseases Hospital were included.NT-proBNP was measured in plasma samples collected from participants at baseline condition.Results At baseline, NT-proBNP was inversely associated with body mass index, waist circumference, fasting glucose, insulin and low-density lipoprotein-cholesterol( LDL-C) levels.During a follow-up of 2 years, 51 participants reported a new diagnosis of diabetes from OGTT.Baseline quartiles of NT-proBNP were inversely associated with diabetes risk, even after multivariable adjustment.Theadjustedrelativerisksfordiabeteswere1.0(reference),0.83(95%CI0.74-0.96),0.78(95%CI 0.68-0.90), 0.74 (95%CI 0.64-0.87) for the 1st, 2nd, 3rd, and 4th quartiles of baseline NT-proBNP, respectively ( P<0.01 ) .Conclus ion In IGRpopulation , lowlevels of NT-proBNP were associated with a significantly increased risk of type 2 diabetes.
