Correlation between Urine HCMV Virus Load and Liver Function Indications among HCMV-Infected Infants
10.3969/j.issn.1671-7414.2016.01.007
- VernacularTitle:HCMV 感染婴儿尿液病毒载量与肝脏损伤指标的相关性分析
- Author:
Erfu XIE
;
Peijun HUANG
;
Zhongjian ZHAO
;
Dan CHEN
;
Bingfeng ZHANG
;
Shiyang PAN
- Publication Type:Journal Article
- Keywords:
human cytomegalovirus;
human cytomegalovirus DNA;
urine;
liver function indications
- From:
Journal of Modern Laboratory Medicine
2016;(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantifying the urine human cytomegalovirus(HCMV)DNA from the HCMV infection infants and its corresponding liver function indications,and investigate the relationship between their concentrations.Methods The u-rine samples were collected from HCMV infection infants.HCMV DNA was measured by fluorescence quantitative polymer-ase chain reaction (FQ-PCR).Serum ALT,AST,ALP,GGT,T-Bil and D-Bil liver function indications were detected and the positive rate was analyzed,simultaneously.The correlation between the logarithm urine HCMV DNA (log HCMV DNA) concentration and ALT,AST,ALP,GGT,T-Bil and D-Bil were analyzed by Spearman correlation analysis.Results The dis-tribution range ofurine log HCMV DNA in 444 HCMV infection infants was <2.70~7.90;the positive rate of serum ALT, AST,ALP,GGT,T-Bil and D-Bil were 24.8%,59.0%,95.7%,31.1%,16.7% and 16.3%,respectively.The urine log HC-MV DNA was associated with GGT and the correlation coefficient was 0.099 (P < 0.05),but no associated with ALT, AST,ALP,T-Bil and D-Bil.Conclusion The positive rate of liver function indications will rise in HCMV infection infants, the urine log HCMV DNA was associated with GGT,but not associated with other liver function indications.
