Diagnostic Value of MicroRNA-499 for Acute Myocardial Infarction:a Meta-Analysis
10.3969/j.issn.1671-7414.2016.01.025
- VernacularTitle:循环 microRNA-499诊断 AMI 的 Meta 分析
- Author:
Gaoming ZHANG
;
Guoming ZHANG
;
Yongjie XIA
- Publication Type:Journal Article
- Keywords:
acute myocardial infarction;
micro RNA-499(MIR-499);
meta analysis
- From:
Journal of Modern Laboratory Medicine
2016;(1):86-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of microRNA-499 (miR-499)levels in acute myocardial infarction (AMI)diagnosis.Methods Retrieve Articles,Wanfang,China Knowledge Network,NCBI PubmMed,EMBSASE database 2010~2015 years met the inclusion criteria published abroad in relation to miR-499 diagnosis ten cases of human AMI litera-ture.The quality of the sudies was evaluated by QUADAS tools through a comprehensive analysis of the random effects model effect size,the use of meta-disc 1.4 software for statistical analysis software.Results Ten studies met the included criteria.The summary estimates for miR-499 diagnosis of MI sensitivity was 83% (95% CI,0.81 ~ 0.85),specificity of 81% (95% CI,0.78~0.83),positive predictive value of 4.53 (95% CI,3.12~ 6.58),negative predictive value was 0.22 (95% CI,0.14~0.33),diagnostic odds ratio 22.73 (95% CI,10.78~47.93).The area under the curve (AUC)for miR-499 was 0.90 with Q value of 0.84.Conclusion MiR-499 has high diagnostic value for acute myocardial infarction.
